Neuroimage. 2003 Jun;19(2 Pt 1):391-401.

Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging.

Wiegell MR, Tuch DS, Larsson HB, Wedeen VJ.

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Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA. mette@nmr.mgh.harvard.edu

Abstract

The nuclei of the thalamus have traditionally been delineated by their distinct cyto/myeloarchitectural appearance on histology. Here, we show that diffusion tensor magnetic resonance imaging (DTI) can noninvasively resolve the major thalamic nuclei based on the characteristic fiber orientation of the corticothalamic/thalamocortical striations within each nucleus. Using an automatic clustering algorithm, we extracted the Talairach coordinates for the individual thalamic nuclei. The center-of-mass coordinates for the segmented nuclei were found to agree strongly with those obtained from a histological atlas. The ability to resolve thalamic nuclei with DTI will allow for morphometric analysis of specific nuclei and improved anatomical localization of functional activation in the thalamus.

PMID:: 12814588; [PubMed - indexed for MEDLINE]

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