Curr Biol. 2003 Jun 17;13(12):R479-81.

Wingless signaling: an axin to grind.

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Department of Biology, Duke University, B336 LSRC, Research Drive, Durham, North Carolina 27708, USA.

Abstract

Negative regulation of Wingless/Wnt signaling plays an important role in embryonic patterning and is also needed for tumor suppression in adult tissues. New findings in Drosophila reveal a novel mechanism for down-regulating the activity of the Wingless/Wnt pathway.

PMID:: 12814566; [PubMed - indexed for MEDLINE]

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Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. [Science. 1999]
Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.
Hamada F, Tomoyasu Y, Takatsu Y, Nakamura M, Nagai S, Suzuki A, Fujita F, Shibuya H, Toyoshima K, Ueno N, et al. Science. 1999 Mar 12; 283(5408):1739-42.
Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli. [Science. 2008]
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Review Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling. [Bioessays. 1994]
Review Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling.
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The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity. [Development. 2007]
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Cited by 6 PubMed Central articles

Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. [J Cell Sci. 2010]
Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.
Jones WM, Chao AT, Zavortink M, Saint R, Bejsovec A. J Cell Sci. 2010 Jul 1; 123(Pt 13):2179-89. Epub 2010 Jun 1.
Canonical wingless signaling regulates cone cell specification in the Drosophila retina. [Dev Dyn. 2010]
Canonical wingless signaling regulates cone cell specification in the Drosophila retina.
Cordero JB, Cagan RL. Dev Dyn. 2010 Mar; 239(3):875-84.
Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. [Oncogene. 2009]
Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.
Jiang Y, Luo W, Howe PH. Oncogene. 2009 Aug 20; 28(33):2999-3007. Epub 2009 Jul 6.

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