Parasitol Res. 2003 Jun;90 Supp 1:S3-9. Epub 2002 Nov 22.

Praziquantel.

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Institute of Cell Biology, C.N.R., 32 Via Ramarini, 00016 Monterotondo (RM), Italy. dcioli@ibc.rm.cnr.it

Abstract

Praziquantel is the drug of choice for the treatment of all forms of schistosomiasis. This review summarizes the main features of the drug, with special attention being given to those aspects that may be of interest to the practicing physician. After a brief mention of the history, the chemistry, the major available brands and their costs, doses and administration schedules are reviewed. Pharmacokinetics and drug interactions are analyzed and the low toxicity and mild side effects are stressed. A major weakness of praziquantel is its relative inefficacy against recent infections, a factor that may occasionally result in low cure rates in hyperendemic areas. Recent findings of schistosome isolates with a decreased sensitivity to praziquantel are discussed in the broader context of a possible emergence of drug resistance.

PMID:: 12811543; [PubMed - indexed for MEDLINE]

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Review Schistosomiasis control: keep taking the tablets. [Trends Parasitol. 2004]
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Cited by 23 PubMed Central articles

Use of Praziquantel as an Adjuvant Enhances Protection and Tc-17 Responses to Killed H5N1 Virus Vaccine in Mice. [PLoS One. 2012]
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Zou Q, Hu Y, Xue J, Fan X, Jin Y, Shi X, Meng D, Wang X, Feng C, Xie X, et al. PLoS One. 2012; 7(4):e34865. Epub 2012 Apr 18.
Solid lipid nanoparticle suspension enhanced the therapeutic efficacy of praziquantel against tapeworm. [Int J Nanomedicine. 2011]
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Xie S, Pan B, Shi B, Zhang Z, Zhang X, Wang M, Zhou W. Int J Nanomedicine. 2011; 6:2367-74. Epub 2011 Oct 18.
Praziquantel facilitates IFN-γ-producing CD8+ T cells (Tc1) and IL-17-producing CD8+ T cells (Tc17) responses to DNA vaccination in mice. [PLoS One. 2011]
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Zou Q, Yao X, Feng J, Yin Z, Flavell R, Hu Y, Zheng G, Jin J, Kang Y, Wu B, et al. PLoS One. 2011; 6(10):e25525. Epub 2011 Oct 5.

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