Release and skin permeation studies of Naproxen from hydrophillic gels and effect of terpenes as enhancers on its skin permeation

Boll Chim Farm. 2003 Apr;142(3):125-9.

Abstract

The skin permeation parameters of Naproxen through albino mouse abdominal skin was investigated. Out of 5 formulations those prepared from carbomer gels showed promising results and were chosen for investigating enhancing effect of various terpene alcohol viz. Geraniol and Nerolidol and cyclic terpenes viz menthol and thymol on skin permeation of Naproxen. Out of the four terpenes studied Geraniol exhibited the highest enhancing effect with enhancement ratio 4.6, while Nerolidol had an enhancement ratio 4.2. The cyclic terpenes had less prompt enhancing effect compared to the alcohol terpenes, out of the two, methol showed the largest effect with an enhancement ratio of about 3.7 and thymol had an enhancement ratio of 3.5.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
  • Chemical Phenomena
  • Chemistry, Physical
  • Excipients
  • Gels
  • Mice
  • Naproxen / administration & dosage
  • Naproxen / pharmacokinetics*
  • Skin / anatomy & histology
  • Skin Absorption / drug effects*
  • Terpenes / pharmacology*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Excipients
  • Gels
  • Terpenes
  • Naproxen