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    FEBS Lett. 2003 Jun 19;545(2-3):151-4.

    The PEF family proteins sorcin and grancalcin interact in vivo and in vitro.

    Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW.

    Source

    Institute of Molecular Biology, Department of Molecular Cell Biology, University of Copenhagen, Oester Farimagsgade 2A, Copenhagen, Denmark.

    Abstract

    The penta-EF hand (PEF) family of calcium binding proteins includes grancalcin, peflin, sorcin, calpain large and small subunits as well as ALG-2. Systematic testing of the heterodimerization abilities of the PEF proteins using the yeast two-hybrid and glutathione S-transferase pull-down assays revealed the new finding that grancalcin interacts strongly with sorcin. In addition, sorcin and grancalcin can be co-immunoprecipitated from lysates of human umbilical vein endothelial cells. Our results indicate that heterodimerization, in addition to differential interactions with target proteins, might be a way to regulate and fine tune processes mediated by calcium binding proteins of the penta-EF hand type.

    PMID:
    12804766
    [PubMed - indexed for MEDLINE]

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