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Cochrane Database Syst Rev. 2003;(2):CD003580.

Heparin for pregnant women with acquired or inherited thrombophilias.

Author information

  • 1Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada, K1H 8L6. mwalker99@hotmail.com

Abstract

BACKGROUND:

Thrombophilias, which are associated with a predisposition to thrombotic events, have been implicated in adverse obstetrical outcomes such as intrauterine growth restriction, stillbirth, severe early onset pre-eclampsia, and placental abruption. Heparin administration in pregnancy may reduce the risk of these events.

OBJECTIVES:

The objective of this review was to assess the effects of heparin on pregnancy outcomes for women with a thrombophilia.

SEARCH STRATEGY:

We searched the Cochrane Pregnancy and Childbirth Group trials register (July 2002), MEDLINE, EMBASE, CINAHL, Scidex (via OVID Technologies - July 2002) and reference lists and personal files.

SELECTION CRITERIA:

Randomized controlled trials comparing heparin with placebo or no treatment, or randomized controlled trials comparing any two treatments. Quasi randomized studies would be included.

DATA COLLECTION AND ANALYSIS:

Data would be abstracted from identified studies and recorded on a paper form by two reviewers.

MAIN RESULTS:

No studies were included.

REVIEWER'S CONCLUSIONS:

There are no completed trials to determine the effects of heparin on pregnancy outcomes for women with a thrombophilia.

PMID:
12804477
[PubMed - indexed for MEDLINE]
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