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Trends Genet. 2003 Jun;19(6):339-44.

Fox's in development and disease.

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  • 1Department of Molecular Genetics, Institute of Ophthalmology, London EC1V 9EL, UK. ojlehmann@yahoo.com


Since the first forkhead (Fox) gene was identified, the importance of this family of transcription factors has increased steadily with the discoveries of the diverse range of developmental processes that they regulate in eukaryotes. Among other processes, the Fox factors are important in the establishment of the body axis and the development of tissues from all three germ layers. In this article, we present some of the recent data on this gene family with reference to selected phenotypes observed in patients and model organisms, and the sensitivity of developmental processes to alterations in forkhead gene dosage.

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