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1: Biochem Biophys Res Commun. 1992 Nov 16;188(3):1146-52.Click here to read Links

An antibody against a CFTR-derived synthetic peptide, incorporated into living submandibular cells, inhibits beta-adrenergic stimulation of mucin secretion.

Mills CL, Pereira MM, Dormer RL, McPherson MA.

Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, U.K.

An antibody raised against a peptide in the first nucleotide-binding domain (NBD) of CFTR [1], incorporated into intact rat submandibular acini by hypotonic swelling, inhibited beta-adrenergic stimulated mucin secretion, without affecting cyclic AMP rise. The data are the first to show that a CFTR-antibody-containing cell results in defective stimulation of mucin secretion, as is seen in CF cells, and that this can be reversed by an excessive increase in cyclic AMP.

PMID: 1280131 [PubMed - indexed for MEDLINE]

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