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1: Biochem Biophys Res Commun. 1992 Nov 16;188(3):1146-52.Click here to read Links

An antibody against a CFTR-derived synthetic peptide, incorporated into living submandibular cells, inhibits beta-adrenergic stimulation of mucin secretion.

Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, U.K.

An antibody raised against a peptide in the first nucleotide-binding domain (NBD) of CFTR [1], incorporated into intact rat submandibular acini by hypotonic swelling, inhibited beta-adrenergic stimulated mucin secretion, without affecting cyclic AMP rise. The data are the first to show that a CFTR-antibody-containing cell results in defective stimulation of mucin secretion, as is seen in CF cells, and that this can be reversed by an excessive increase in cyclic AMP.

PMID: 1280131 [PubMed - indexed for MEDLINE]

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