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Appl Radiat Isot. 2003 Jun;58(6):657-66.

Improved synthesis of anti-[18F]FACBC: improved preparation of labeling precursor and automated radiosynthesis.

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  • 1Department of Radiology, EUH, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA.


The non-natural amino acid anti-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid (FACBC) has shown promise for tumor imaging with positron emission tomography. An improved synthesis of the precursor of anti-[18F]FACBC has been devised which demonstrates high stereoselectivity and suitability for large-scale preparations. An automated radiosynthesis has been developed which provides anti-[18F]FACBC in 24% decay-corrected yield. Additionally, the major non-radioactive species present in doses of anti-[18F]FACBC has been identified as anti-1-amino-3-hydroxycyclobutane-1-carboxylic acid. Together, these results are important steps towards the routine production of anti-[18F]FACBC for human use.

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