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Bioorg Med Chem Lett. 2003 Jul 7;13(13):2231-4.

Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors.

Author information

  • 1Cubist Pharmaceutical Inc., 65 Hayden Ave., 02421, Lexington, MA, USA. john.finn@cubist.com

Abstract

Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase.

PMID:
12798340
[PubMed - indexed for MEDLINE]
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