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Neuron. 2003 Jun 5;38(5):685-8.

Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis.

Author information

  • 1Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. zamvil@ucsf.neuroimmunol.org

Abstract

Multiple sclerosis (MS) is an autoimmune central nervous system (CNS) demyelinating disease that causes relapsing and chronic neurologic impairment. Recent observations have altered certain traditional concepts regarding MS pathogenesis. A greater diversity of cell types and molecules involved in MS is now evident. While remyelination can occur during the early inflammatory phase when damage may be reversible, it is impaired in the later stages, which involve axonal death. These observations have important therapeutic implications.

PMID:
12797954
[PubMed - indexed for MEDLINE]
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