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Neurology. 2003 Jun 10;60(11):1854-7.

Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2.

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  • 1Department of Neurology, Vaasa Central Hospital, Vaasa, Finland.

Abstract

Muscle biopsy findings in DM2 have been reported to be similar to those in DM1. The authors used myosin heavy chain immunohistochemistry and enzyme histochemistry for fiber type differentiation on muscle biopsies. Their results show that DM2 patients display a subpopulation of type 2 nuclear clump and other very small fibers and, hence, preferential type 2 fiber atrophy in contrast to type 1 fiber atrophy in DM1 patients.

PMID:
12796551
[PubMed - indexed for MEDLINE]
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