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Recent Prog Horm Res. 2003;58:249-61.

Paired-like repression/activation in pituitary development.

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  • 1Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, California 92093-0648, USA.


Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/Rpx and activator prophet of Pit-1 (Prop-1), which exert selective roles during pituitary development. The opposing actions of these factors provide one aspect of pituitary organogenesis.

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