Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 1992 Nov 19;360(6401):232-9.

Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.

Author information

  • 1Laboratory of Molecular Biophysics, Oxford, UK.

Abstract

The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.

PMID:
1279440
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk