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J Mol Neurosci. 2003 Apr;20(2):203-6.

The relationship between amyloid and tau.

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  • 1Laboratory of Neurogenetics, NIA/NIH, Building 10, 6C103, Bethesda, MD 20892, USA.


Based on genetic findings, the relationship between the APP/Abeta and tau/tangle pathologies are discussed. It is argued that APP/Abeta is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Abeta can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.

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