J Med Screen. 2003;10(1):2-4.

False-negative primary neonatal thyroid screening: the need for clinical vigilance and secondary screening.

Yunis KA, Nasr MR, Lepejian G, Najjar S, Daher R.

Source

Department of Pediatrics, Daher, American University of Beirut, Beirut, Lebanon. kayunis@aub.edu.lb

Abstract

The screening of newborn babies for congenital hypothyroidism has changed the natural history of this abnormality. We describe here a case of a female patient with congenital hypothyroidism that was missed by primary neonatal thyroid screening (using thyroid-stimulating hormone) at two days of age; it was detected only after the development and persistence of jaundice during the first three weeks of life. A normal neonatal screening result does not preclude the development of hypothyroidism later in infancy. Clinical vigilance must be maintained by practitioners. A second screening between two and six weeks of age may be useful in order to detect the few cases missed at first screening.

PMID:: 12790307; [PubMed - indexed for MEDLINE]

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Thyrotropin

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