J Neurocytol. 1975 Dec;4(6):745-57.

Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the rat.

Abstract

Focal areas of primary demyelination were produced in the spinal cords of rats by means of local injections of 6-aminonicotinamide. Both astrocytes and oligodendrocytes underwent degeneration in the demyelinated area. Nearly all the demyelinated axons were remyelinated by Schwann cells; only a very small number of axons located adjacent to normally myelinated axons were remyelinated by oligodendrocytes. The glial limiting membrane was reconstituted around the ecge of the area remyelinated by Schwann cells. This experiment offers further evidence for an important role of astrocytes in controlling Schwann cell invasion of the central nervous system, and in addition suggests that astrocytes are also needed for oligodendrocyte remyelination to take place.

PMID:: 127832; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin. [J Neurol Sci. 1977]
Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin.
Blakemore WF, Eames RA, Smith KJ, McDonald WI. J Neurol Sci. 1977 Aug; 33(1-2):31-43.
Lesions in the cat spinal cord following local injections of 6-aminonicotinamide. [Res Vet Sci. 1978]
Lesions in the cat spinal cord following local injections of 6-aminonicotinamide.
Blakemore WF. Res Vet Sci. 1978 May; 24(3):390-1.
Schwann cell and oligodendrocyte remyelination in lysolecithin-induced lesions in irradiated rat spinal cord. [J Neurol Sci. 1985]
Schwann cell and oligodendrocyte remyelination in lysolecithin-induced lesions in irradiated rat spinal cord.
Harrison B. J Neurol Sci. 1985 Feb; 67(2):143-59.
Review Transplanted cultured type-1 astrocytes can be used to reconstitute the glia limitans of the CNS: the structure which prevents Schwann cells from myelinating CNS axons. [Neuropathol Appl Neurobiol. 1992]
Review Transplanted cultured type-1 astrocytes can be used to reconstitute the glia limitans of the CNS: the structure which prevents Schwann cells from myelinating CNS axons.
Blakemore WF. Neuropathol Appl Neurobiol. 1992 Oct; 18(5):460-6.
Review The role of oligodendrocytes and oligodendrocyte progenitors in CNS remyelination. [Adv Exp Med Biol. 1999]
Review The role of oligodendrocytes and oligodendrocyte progenitors in CNS remyelination.
Keirstead HS, Blakemore WF. Adv Exp Med Biol. 1999; 468:183-97.

See reviews... See all...

Cited by 4 PubMed Central articles

Schwann cell-like differentiation by adult oligodendrocyte precursor cells following engraftment into the demyelinated spinal cord is BMP-dependent. [Glia. 2006]
Schwann cell-like differentiation by adult oligodendrocyte precursor cells following engraftment into the demyelinated spinal cord is BMP-dependent.
Talbott JF, Cao Q, Enzmann GU, Benton RL, Achim V, Cheng XX, Mills MD, Rao MS, Whittemore SR. Glia. 2006 Aug 15; 54(3):147-59.
Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler's virus. [Am J Pathol. 1980]
Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler's virus.
Dal Canto MC, Lipton HL. Am J Pathol. 1980 Jan; 98(1):101-22.
Remyelination during remission in Theiler's virus infection. [Am J Pathol. 1984]
Remyelination during remission in Theiler's virus infection.
Dal Canto MC, Barbano RL. Am J Pathol. 1984 Jul; 116(1):30-45.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Remyelination by Schwann cells of axons demyelinated by intraspinal injection of...
Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the rat.
J Neurocytol. 1975 Dec ;4(6):745-57.

PubMed
Single breath-hold real-time cine MR imaging: improved temporal resolution using...
Single breath-hold real-time cine MR imaging: improved temporal resolution using generalized autocalibrating partially parallel acquisition (GRAPPA) algorithm.
Eur Radiol. 2003 Aug ;13(8):1931-6. Epub 2003 May 29 .

PubMed
Experimental muscle pain changes feedforward postural responses of the trunk mus...
Experimental muscle pain changes feedforward postural responses of the trunk muscles.
Exp Brain Res. 2003 Jul ;151(2):262-71. Epub 2003 Jun 3 .

PubMed
RPE, pain, and physiological adjustment to concentric and eccentric contractions...
RPE, pain, and physiological adjustment to concentric and eccentric contractions.
Med Sci Sports Exerc. 2003 Jun ;35(6):1017-25.

PubMed
Effects of oral creatine and resistance training on myogenic regulatory factor e...
Effects of oral creatine and resistance training on myogenic regulatory factor expression.
Med Sci Sports Exerc. 2003 Jun ;35(6):923-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the rat.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information