Abstract
Tissue tropism of clinical ocular and genital Chlamydia trachomatis strains is shown to be linked to the tryptophan synthase genotype. It is suggested that, in the presence of IFN-gamma, which depletes available tryptophan, there exist unique host-parasite interactions that may contribute to persistent chlamydial infection.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Chlamydia Infections / genetics*
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Chlamydia Infections / therapy*
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Female
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Genitalia, Female / microbiology
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Humans
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Interferon-gamma / metabolism
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Models, Biological
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Tryptophan Synthase / genetics*
Substances
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Interferon-gamma
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Tryptophan Synthase