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Int J Parasitol. 2003 May;33(5-6):495-505.

Haemolysin A and listeriolysin--two vaccine delivery tools for the induction of cell-mediated immunity.

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  • 1Vaccine Research, Berna Biotech AG, Rehhagstr. 79, CH-3018, Bern, Switzerland. guido.dietrich@bernabiotech.com

Abstract

Haemolysin A of Escherichia coli and listeriolysin of Listeria monocytogenes represent important bacterial virulence factors. While such cytolysins are usually the reason for morbidity and even mortality, vaccine researchers have turned haemolysin A and listeriolysin into tools for vaccine delivery. Both cytolysins have found widespread application in vaccine research and are highly suitable for the elicitation of cell-mediated immunity. In this paper, we will review vaccine delivery mediated by the haemolysin A secretion system and listeriolysin and will highlight their use in vaccination approaches against protozoan parasites.

PMID:
12782050
[PubMed - indexed for MEDLINE]
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