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Nat Rev Mol Cell Biol. 2003 Jun;4(6):491-7.

When ubiquitin meets ubiquitin receptors: a signalling connection.

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  • 1Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy.


Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation is rapidly induced by signalling events and allows the establishment of protein-protein interactions between monoubiquitylated proteins and partners that contain distinct ubiquitin-binding domains. We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation.

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