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Nat Rev Mol Cell Biol. 2003 Jun;4(6):457-67.

Killing the messenger: short RNAs that silence gene expression.

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  • 1Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-529, Cambridge, Massachusetts 02139, USA.


Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.

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