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Nat Rev Mol Cell Biol. 2003 Jun;4(6):446-56.

Rocks: multifunctional kinases in cell behaviour.

Author information

  • 1Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK. kirsi@ludwig.ucl.ac.uk

Abstract

ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.

PMID:
12778124
[PubMed - indexed for MEDLINE]
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