Nat Rev Mol Cell Biol. 2003 Jun;4(6):435-45.

Molecular views of recombination proteins and their control.

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Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK. stephen.west@cancer.org.uk

Abstract

The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome stability and cell survival. Homologous recombination provides an efficient and faithful pathway of repair, especially in replicating cells, in which it plays a major role in tumour avoidance. Many of the enzymes that are involved in recombination have been isolated, and the details of this pathway are now being unravelled at the molecular level.

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Molecular views of recombination proteins and their control.

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