Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Am Diet Assoc. 2003 Jun;103(6):707-12.

A prospective study: growth and nutritional status of children treated with the ketogenic diet.

Author information

  • 1The Hospital for Sick Children, Room 6D47 Atrium, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8. christiana.liu@sickkids.ca

Abstract

OBJECTIVE:

To assess the nutritional status of children treated with the classic and medium-chain triglyceride (MCT) ketogenic diets.

DESIGN:

A prospective, nonrandomized study design was used to measure nutrient intakes, growth, and biochemical indexes of children, age 1 to 16 years, with intractable epilepsy before and after 4 months' treatment with the classic and MCT ketogenic diets. None of the children had been on earlier dietary regimens.

SUBJECTS:

Of 58 children asked to participate in the study between September 1998 and July 2000, consent was obtained for 30 children. Fourteen children on the classic diet and 11 children on the MCT diet completed the study (83% completed). Statistical analysis performed Paired t tests were done on anthropometric and biochemical indexes. Nutrient intakes were compared with Dietary Reference Intakes (DRIs).

RESULTS:

Both groups had statistically significant height increases of 2 to 3 cm (P<.05), but did not have significant increases in height/age percentiles. Weight percentiles decreased by approximately 10 percentiles for both diets; P=.043 for classic diet and.051 for MCT diet. Nutrient intakes from the diet and vitamin and mineral supplements met the DRIs except for phosphorus (both diets) and folate (classic diet). All biochemical indexes, including albumin, remained within the normal range. For the MCT diet, there was a 0.7 decrease in the ratio of total cholesterol to high-density lipoprotein ratios (P<.0009) at 4 months.

APPLICATIONS:

When treating children on a ketogenic diet, clinicians should recommend adequate intake of energy and protein, a higher proportion of unsaturated to saturated dietary fats, and consider vitamin and mineral supplements.

PMID:
12778041
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk