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Nihon Yakurigaku Zasshi. 2003 Apr;121(4):233-40.

Alternative splicing of Cav2 genes and their functional significance.

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  • 1Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan. skaneko@pharm.kyoto-u.ac.jp

Abstract

Alternative splicing is one of the most pharmacologically and physiologically significant mechanisms for the functional diversity of the mammalian genomes. Here I review recent results on the diversity of the Ca(v)2 subclass of voltage-dependent Ca(2+) channel gene in neurons. Although the entire picture of alternative splicing is not yet understood, emerging evidences suggest the Ca(v)2 isoforms permit optimization of Ca(2+) signaling in different regions of the brain with specific pharmacological ligands.

PMID:
12777842
[PubMed - indexed for MEDLINE]
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