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Nihon Yakurigaku Zasshi. 2003 Apr;121(4):233-40.

Alternative splicing of Cav2 genes and their functional significance.

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  • 1Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.


Alternative splicing is one of the most pharmacologically and physiologically significant mechanisms for the functional diversity of the mammalian genomes. Here I review recent results on the diversity of the Ca(v)2 subclass of voltage-dependent Ca(2+) channel gene in neurons. Although the entire picture of alternative splicing is not yet understood, emerging evidences suggest the Ca(v)2 isoforms permit optimization of Ca(2+) signaling in different regions of the brain with specific pharmacological ligands.

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