Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Microbiology. 2003 Jun;149(Pt 6):1367-75.

Arming the enemy: the evolution of resistance to self-proteins.

Author information

  • 1Biology Department, McGill University, 1205 Ave Dr Penfield, Montreal, Qu├ębec, Canada H3A 1B1. graham.bell@mcgill.ca

Abstract

A remarkable range of novel antibiotics is attracting increasing interest as a major new weapon in the campaign against bacterial infection. They are based on the toxic peptides that provide the innate immune system of animals, and it is claimed that bacteria will be unable to evolve resistance to them because they attack the 'Achilles' heel' of bacterial membrane structure. Both experimental evidence and theoretical arguments suggest that this claim is doubtful. If so, the introduction of these substances into general use may provoke the evolution of resistance to our own defence proteins and thus compromise our natural defences against infection.

Comment in

PMID:
12777478
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk