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Nat Rev Genet. 2003 Jun;4(6):478-82.

Modelling genitourinary defects in mice: an emerging genetic and developmental system.

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  • 1Shriners Hospital for Children and the Oregon Health and Science University, 3101 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. hss@shcc.org


The rising incidence of genitourinary (GU) defects among newborns establishes the need and opportunity to focus research efforts on the amelioration of this growing public-health concern. Sadly, our inability to explain the causes of GU defects can be directly attributed to our lack of understanding of GU gene function. Recently, mouse models have been used to provide new insights into the mechanisms that underlie congenital GU malformations.

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