EMBO Rep. 2003 Jun;4(6):571-4.

IQGAP proteins are integral components of cytoskeletal regulation.

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Brigham and Women's Hospital, Thorn 530, 75 Francis Street, Boston, MA 02115, USA.

Abstract

IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural molecules. By interacting with its target proteins, human IQGAP1 participates in multiple cellular functions, including Ca(2+)/calmodulin signalling, cytoskeletal architecture, CDC42 and Rac signalling, E-cadherin-mediated cell-cell adhesion and beta-catenin-mediated transcription. Yeast IQGAP homologues are important regulators of cellular morphogenesis because they are required for budding and cytokinesis. Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.

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PMCID:: PMC1319206

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Review IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton. [FEBS Lett. 2003]
Review IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
Briggs MW, Sacks DB. FEBS Lett. 2003 May 8; 542(1-3):7-11.
IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. [J Biol Chem. 2002]
IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin.
Briggs MW, Li Z, Sacks DB. J Biol Chem. 2002 Mar 1; 277(9):7453-65. Epub 2001 Dec 4.
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Kuroda S, Fukata M, Nakagawa M, Kaibuchi K. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):1-6.
Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin. [J Biol Chem. 1999]
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Fukata M, Kuroda S, Nakagawa M, Kawajiri A, Itoh N, Shoji I, Matsuura Y, Yonehara S, Fujisawa H, Kikuchi A, et al. J Biol Chem. 1999 Sep 10; 274(37):26044-50.

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Cited by 46 PubMed Central articles

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