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Biochem Soc Trans. 2003 Jun;31(Pt 3):648-51.

Toll and Toll-like receptors in Drosophila.

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  • 1UPR9022 CNRS, 15 rue RenĂ© Descartes, 67084 Strasbourg Cedex, France.


The Drosophila Toll receptor controls the immune response to Gram-positive bacteria and fungi by activating a signalling pathway partially conserved throughout evolution. The Drosophila genome encodes eight additional Toll-related receptors, most of which appear to carry out developmental rather than immune functions. One exception may be Toll-9, which shares structural and functional similarities with mammalian TLRs.

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