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Biochem Soc Trans. 2003 Jun;31(Pt 3):497-501.

Electron transfer in human cytochrome P450 reductase.

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  • 1Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK.


Cytochrome P450 reductase (CPR) is a diflavin enzyme responsible for electron donation to mammalian cytochrome P450 enzymes in the endoplasmic reticulum. Dissection of the enzyme into functional domains and studies by site-directed mutagenesis have enabled detailed characterization of the mechanism of electron transfer using stopped-flow and equilibrium-perturbation methods, and redox potentiometry. These studies and the mechanism of electron transfer in CPR are reported herein.

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