Br J Cancer. 2003 Jun 2;88(11):1713-20.

Human papillomavirus infection and use of oral contraceptives.

Green J, Berrington de Gonzalez A, Smith JS, Franceschi S, Appleby P, Plummer M, Beral V.

Source

Cancer Research UK Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, UK. Jane.Green@cancer.org.uk

Abstract

Human papillomavirus (HPV) infection is thought to be a necessary but not sufficient cause of most cases of cervical cancer. Since oral contraceptive use for long durations is associated with an increased risk of cervical cancer, it is important to know whether HPV infection is more common in oral contraceptive users. We present a systematic review of 19 epidemiological studies of the risk of genital HPV infection and oral contraceptive use. There was no evidence for a strong positive or negative association between HPV positivity and ever use or long duration use of oral contraceptives. The limited data available, the presence of heterogeneity between studies and the possibility of bias and confounding mean, however, that these results must be interpreted cautiously. Further studies are needed to confirm these findings and to investigate possible relations between oral contraceptive use and the persistence and detectability of cervical HPV infection.

PMID:: 12771986; [PubMed - indexed for MEDLINE]
PMCID:: PMC2377143

Free PMC Article

Images from this publication.See all images (6) Free text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Contraceptives, Oral

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Association of oral contraceptive use and human papillomaviruses in invasive cervical cancers. [Int J Cancer. 1990]
Association of oral contraceptive use and human papillomaviruses in invasive cervical cancers.
Hildesheim A, Reeves WC, Brinton LA, Lavery C, Brenes M, De La Guardia ME, Godoy J, Rawls WE. Int J Cancer. 1990 May 15; 45(5):860-4.
Review The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review. [Int J Gynecol Cancer. 2003]
Review The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review.
Moodley M, Moodley J, Chetty R, Herrington CS. Int J Gynecol Cancer. 2003 Mar-Apr; 13(2):103-10.
Oral contraceptive use and human papillomavirus infection in women without abnormal cytological results. [Med Microbiol Immunol. 1992]
Oral contraceptive use and human papillomavirus infection in women without abnormal cytological results.
Veress G, Csiky-Mészáros T, Czeglédy J, Gergely L. Med Microbiol Immunol. 1992; 181(4):181-9.
Review Chapter 3: Cofactors in human papillomavirus carcinogenesis--role of parity, oral contraceptives, and tobacco smoking. [J Natl Cancer Inst Monogr. 2003]
Review Chapter 3: Cofactors in human papillomavirus carcinogenesis--role of parity, oral contraceptives, and tobacco smoking.
Castellsagué X, Muñoz N. J Natl Cancer Inst Monogr. 2003; (31):20-8.
Human papillomavirus and long-term oral contraceptive use increase the risk of adenocarcinoma in situ of the cervix. [Cancer Epidemiol Biomarkers Pr...]
Human papillomavirus and long-term oral contraceptive use increase the risk of adenocarcinoma in situ of the cervix.
Madeleine MM, Daling JR, Schwartz SM, Shera K, McKnight B, Carter JJ, Wipf GC, Critchlow CW, McDougall JK, Porter P, et al. Cancer Epidemiol Biomarkers Prev. 2001 Mar; 10(3):171-7.

See reviews... See all...

Cited by 10 PubMed Central articles

Determinants of seropositivity among HPV-16/18 DNA positive young women. [BMC Infect Dis. 2010]
Determinants of seropositivity among HPV-16/18 DNA positive young women.
Porras C, Bennett C, Safaeian M, Coseo S, Rodríguez AC, González P, Hutchinson M, Jiménez S, Sherman ME, Wacholder S, et al. BMC Infect Dis. 2010 Aug 11; 10:238. Epub 2010 Aug 11.
Acquisition of high-risk human papillomavirus infection in a population-based cohort of Danish women. [Sex Transm Dis. 2009]
Acquisition of high-risk human papillomavirus infection in a population-based cohort of Danish women.
Nielsen A, Iftner T, Munk C, Kjaer SK. Sex Transm Dis. 2009 Oct; 36(10):609-15.
Human papillomavirus infection in Beijing, People's Republic of China: a population-based study. [Br J Cancer. 2009]
Human papillomavirus infection in Beijing, People's Republic of China: a population-based study.
Zhao R, Zhang WY, Wu MH, Zhang SW, Pan J, Zhu L, Zhang YP, Li H, Gu YS, Liu XZ. Br J Cancer. 2009 Nov 3; 101(9):1635-40. Epub 2009 Sep 29.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Human papillomavirus infection and use of oral contraceptives.
Human papillomavirus infection and use of oral contraceptives.
Br J Cancer. 2003 Jun 2 ;88(11):1713-20.

PubMed
Lifestyles, environmental and phenotypic factors associated with lip cancer: a c...
Lifestyles, environmental and phenotypic factors associated with lip cancer: a case-control study in southern Spain.
Br J Cancer. 2003 Jun 2 ;88(11):1702-7.

PubMed
Pretreatment with statins enhances myocardial protection during coronary revascu...
Pretreatment with statins enhances myocardial protection during coronary revascularization.
J Thorac Cardiovasc Surg. 2003 May ;125(5):1037-42.

PubMed
Efficacy of a 6-month treatment with Daflon 500 mg in patients with venous leg u...
Efficacy of a 6-month treatment with Daflon 500 mg in patients with venous leg ulcers associated with chronic venous insufficiency.
Int Angiol. 2003 Mar ;22(1):24-31.

PubMed
Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen.
Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen.
J Urol. 2003 Jun ;169(6):2200-2.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: