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Neurology. 2003 May 27;60(10):1713-6.

Differential activation on fMRI of monozygotic twins discordant for AD.

Author information

  • 1Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Texas 75390-9070, USA. anne.lipton@utsouthwestern.edu

Abstract

This is the first report of fMRI in monozygotic twins discordant for AD. FMRI brain activation patterns were examined during visuospatial and verbal working memory tasks. The affected twin had greater parietal involvement bilaterally during both working memory tasks and reduced left dorsolateral prefrontal cortex activity on the visuospatial memory task. Thus, fMRI may identify additional brain regions recruited in patients with AD to perform a given cognitive task.

PMID:
12771278
[PubMed - indexed for MEDLINE]
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