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Trends Biochem Sci. 2003 May;28(5):224-6.

HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins.

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  • 1Program in Bioinformatics and Systems Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.


A novel domain - HEPN (higher eukarytoes and prokaryotes nucleotide-binding domain) - found in several bacterial species is also present in the human protein, sacsin, a chaperonin implicated in an early-onset neurodegenerative disease. The distant structural similarity suggests that this domain might be involved in nucleotide binding.

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