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Science. 2003 May 23;300(5623):1288-91.

The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons.

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  • 1Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.

Abstract

Alu repetitive elements can be inserted into mature messenger RNAs via a splicing-mediated process termed exonization. To understand the molecular basis and the regulation of the process of turning intronic Alus into new exons, we compiled and analyzed a data set of human exonized Alus. We revealed a mechanism that governs 3' splice-site selection in these exons during alternative splicing. On the basis of these findings, we identified mutations that activated the exonization of a silent intronic Alu.

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PMID:
12764196
[PubMed - indexed for MEDLINE]
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