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Eur Psychiatry. 2003 May;18(3):133-6.

Substance use and the course of early psychosis: a 2-year follow-up of first-admitted subjects.

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  • 1Department of Psychiatry, University Victor Segalen, Bordeaux 2, France.

Abstract

OBJECTIVE:

To examine the impact of alcohol and substance use on the early course of psychosis.

METHODS:

First-admitted subjects with psychosis (n = 58) were assessed at 6-month intervals over a 2-year follow-up. Information on substance and alcohol misuse and clinical and social outcome was collected using multiple sources of information.

RESULTS:

After adjustment for potential confounding factors, subjects with persistent substance misuse over the follow-up were at increased risk of readmission (OR = 3.1; 95%CI = 1.0-9.4; P = 0.05), of presenting with psychotic symptoms (OR = 4.3; 95%CI = 1.0-18.1; P = 0.04), and with a non-continuous course of illness (OR = 11; 95%CI = 1-122; P = 0.05). No significant association was found between substance misuse and social outcome, or between alcohol misuse and clinical and social outcome.

CONCLUSION:

Persistent substance misuse after a first admission for psychosis has a deleterious impact on clinical outcome. Early identification and treatment of substance use is essential in the care of subjects with incipient psychosis.

PMID:
12763300
[PubMed - indexed for MEDLINE]
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