ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp. F-1490. I. Taxonomy, fermentation, isolation and biological activities

Hiroyuki Inoue; Hiroyuki Kumagai; Michiyo Osono; Motoko Matsufuji; Tomohiro Sameshima; Naoto Kawamura; Tetsuya Someno; Masaaki Ishizuka; Tomio Takeuchi

doi:10.7164/antibiotics.56.209

ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp. F-1490. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 2003 Mar;56(3):209-13. doi: 10.7164/antibiotics.56.209.

Authors

Hiroyuki Inoue¹, Hiroyuki Kumagai, Michiyo Osono, Motoko Matsufuji, Tomohiro Sameshima, Naoto Kawamura, Tetsuya Someno, Masaaki Ishizuka, Tomio Takeuchi

Affiliation

¹ Institute for Chemotherapy, M. C. R. F., 18-24 Miyamoto, Numazu-shi, Shizuoka, 410-0301, Japan.

PMID: 12760675
DOI: 10.7164/antibiotics.56.209

Abstract

In the course of screening for inhibitors of osteoclastogenesis, a new substance designated as ICM0201 was isolated from a fermentation broth of Cunninghamella sp. F-1490. ICM0201 inhibited the formation of osteoclasts in mouse bone marrow cells with an IC50 value of 0.78 microg/ml and showed weak cytotoxicity against bone marrow cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / classification*
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Cunninghamella / chemistry*
Fermentation
Heterocyclic Compounds, 3-Ring / classification*
Heterocyclic Compounds, 3-Ring / isolation & purification
Heterocyclic Compounds, 3-Ring / metabolism
Heterocyclic Compounds, 3-Ring / pharmacology
Male
Mice
Mice, Inbred C57BL
Oxazines / classification*
Oxazines / isolation & purification
Oxazines / metabolism
Oxazines / pharmacology
Tumor Cells, Cultured

Substances

Anti-Bacterial Agents
Heterocyclic Compounds, 3-Ring
ICM 0201
Oxazines