Sci STKE. 2003 May 20;2003(183):pe20.

Do filopodia enable the growth cone to find its way?

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Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Box 208024, 333 Cedar Street, New Haven, CT 06520-8024, USA. anthony.koleske@yale.edu

Abstract

Ena/VASP family proteins are required for accurate axon pathfinding in developing Drosophila, Caenorhabditis elegans, and mouse nervous systems. Recent papers by Bear et al. and Svitkina et al. provide evidence that Ena/VASP proteins regulate actin filament elongation in the lamellipodia and filopodia of nonneuronal cells. Neuronal growth cones use filopodia as their "sensory organs" that steer the growth cone by reading guidance cues in the environment. Together, these studies suggest that Ena/VASP proteins regulate axon guidance by controlling the formation or rearrangement of growth cone filopodia.

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Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. [Neuron. 2004]
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.
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Review Ena/VASP: proteins at the tip of the nervous system. [Curr Opin Neurobiol. 2008]
Review Ena/VASP: proteins at the tip of the nervous system.
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Cited by 5 PubMed Central articles

Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization. [Mol Cell Biol. 2010]
Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.
Robens JM, Yeow-Fong L, Ng E, Hall C, Manser E. Mol Cell Biol. 2010 Feb; 30(3):829-44. Epub 2009 Nov 23.
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). [PLoS Biol. 2009]
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).
Menna E, Disanza A, Cagnoli C, Schenk U, Gelsomino G, Frittoli E, Hertzog M, Offenhauser N, Sawallisch C, Kreienkamp HJ, et al. PLoS Biol. 2009 Jun 30; 7(6):e1000138. Epub 2009 Jun 30.
Review Ena/VASP: proteins at the tip of the nervous system. [Curr Opin Neurobiol. 2008]
Review Ena/VASP: proteins at the tip of the nervous system.
Drees F, Gertler FB. Curr Opin Neurobiol. 2008 Feb; 18(1):53-9. Epub 2008 May 26.

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