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Cell. 2003 May 16;113(4):422-3.

Fusion with the fused: a new role for interleukin-4 in the building of muscle.

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  • 1Molecular Medicine Program, Ottawa Health Research Institute, Ontario, Canada.


In this issue of Cell, G. Pavlath and coworkers demonstrate a novel role for Interleukin-4 (IL-4) in regulating the fusion of myoblasts with differentiated myotubes. The authors demonstrate that NFATc2 signaling in newly formed myotubes induces IL-4 expression and secretion which promotes myoblast fusion with pre-existing myotubes.

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