Nat Med. 2003 Jun;9(6):727-8. Epub 2003 May 18.

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

Siliciano JD, Kajdas J, Finzi D, Quinn TC, Chadwick K, Margolick JB, Kovacs C, Gange SJ, Siliciano RF.

Source

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.

Abstract

Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.

PMID:: 12754504; [PubMed - indexed for MEDLINE]

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RNA, Viral

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AI43222/AI/NIAID NIH HHS/United States

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