Olanzapine in the treatment-resistant, combat-rela...[Acta Psychiatr Scand. 2003]

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1: Acta Psychiatr Scand. 2003 May;107(5):394-6; discussion 396. Links

Olanzapine in the treatment-resistant, combat-related PTSD--a series of case reports.

Jakovljević M, Sagud M, Mihaljević-Peles A.

Department of Psychiatry, University Hospital Center Zagreb, Zagreb-Rebro, Croatia.

OBJECTIVE: Nightmares and insomnia in combat-related post-traumatic stress disorder (PTSD) might be resistant to treatment with selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines. METHOD: We describe five case reports of patients suffering from long-lasting and intractable nightmares and insomnia. They were given different psychotropic agents in past few years, with no improvement in their sleep disturbance. Olanzapine was added to the current treatment regimen. RESULTS: Both nightmares and insomnia improved rapidly after olanzapine institution in all of five patients. No adverse events of olanzapine were reported. CONCLUSION: Olanzapine augmentation might be useful in alleviating treatment-resistant nightmares and insomnia in patients with combat-related PTSD.

PMID: 12752037 [PubMed - indexed for MEDLINE]

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Olanzapine (Zyprexa®, Zydis®, Symbyax® (as a combination product containing Olanzapine and Fluoxetine Hydrochloride)) Olanzapine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). It is also used to treat bipolar dis...

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Olanzapine in the treatment-resistant, combat-related PTSD--a series of case reports.

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