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Leukemia. 2003 May;17(5):960-4.

Human cord blood long-term engrafting cells are CD34+ CD38-.

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  • 1Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC 29401, USA.

Abstract

There have been controversies about CD34 and CD38 expression by human cord blood (CB) stem cells. Using the newborn NOD/SCID/beta2-microglobulin-null mouse assay that we recently developed, we examined the in vivo engrafting capability of human CB cells. Almost all of the 4-5 months engrafting cells were found in CD34(+) population. The capability of secondary reconstitution was found only in the CD34(+) cells. When the CD34(+) CB cells were separated into CD38(-) and CD38(+) subpopulations and tested for engraftment, the majority of the engrafting cells were detected in the CD38(-) subpopulation. These findings are consistent with the results from studies of murine stem cells and strongly indicate that the phenotype of human CB stem cells is CD34(+) CD38(-).

PMID:
12750710
[PubMed - indexed for MEDLINE]
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