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Science. 2003 May 16;300(5622):1142-5.

Regulation of aging and age-related disease by DAF-16 and heat-shock factor.

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  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-2200, USA.

Erratum in

  • Science. 2003 Jun 27;300(5628):2033.

Abstract

The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends lifespan. We find that HSF-1, like the transcription factor DAF-16, is required for daf-2-insulin/IGF-1 receptor mutations to extend life-span. Our findings suggest this is because HSF-1 and DAF-16 together activate expression of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevity. The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease.

PMID:
12750521
[PubMed - indexed for MEDLINE]
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