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Fertil Steril. 2003 Apr;79(4):975-80.

Serum concentrations of interleukin-2R (IL-2R), IL-6, IL-8, and tumor necrosis factor alpha in patients with ectopic pregnancy.

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  • 1Service de Gynécologie, Hôpital Hôtel-Dieu, Université Broussais-Hôtel-Dieu, Assistance Public des Hôpitaux de Paris, and INSERM U327, Université Paris, Paris, France.

Abstract

OBJECTIVE:

To investigate the diagnostic relevance of serum cytokine concentrations in ectopic pregnancy (EP).

DESIGN:

Cohort study.

SETTING:

University hospital.

PATIENT(S):

Seventeen women with EP, 22 women with miscarriage, and 33 women with normal intrauterine pregnancy, at comparable stages of gestation.

INTERVENTION(S):

Interleukin (IL)-2 receptor, IL-6, IL-8, and tumor necrosis factor alpha (TNF-alpha) determination by immunoradiometric assay.

MAIN OUTCOME MEASURE(S):

Serum concentrations of progesterone, beta-hCG, IL-2R, IL-6, IL-8, and TNF-alpha.

RESULT(S):

Serum levels of IL-6 were higher in women with EP than in those with miscarriage and normal pregnancy. Serum levels of TNF-alpha were higher in women with EP than in those with miscarriage and normal pregnancy. Serum levels of IL-8 were higher in women with EP than in those with miscarriage and normal pregnancy. An IL-8 cutoff of >40 pg/mL predicted EP with a sensitivity of 82.4%, a specificity of 81.8%, and positive and negative predictive values of 58.3% and 93.8%. No difference in serum IL-2R levels was found among the groups.

CONCLUSION(S):

Serum IL-8, IL-6, and TNF-alpha concentrations are higher in women with EP than in those with miscarriage and normal pregnancy. Further studies are needed to determine their diagnostic value.

PMID:
12749440
[PubMed - indexed for MEDLINE]
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