Lancet. 2003 May 10;361(9369):1615-7.

Development of a standard treatment protocol for severe acute respiratory syndrome.

So LK, Lau AC, Yam LY, Cheung TM, Poon E, Yung RW, Yuen KY.

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Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Special Administrative Region, China. drcwlau@hkstar.com

Abstract

A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterials and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.

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Lancet. 2003 Dec 13;362(9400):2025-6.

PMID:: 12747883; [PubMed - indexed for MEDLINE]

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