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Clin Infect Dis. 2003 May 15;36(10):e122-6. Epub 2003 May 9.

Prolonged perilesional edema after treatment of parenchymal neurocysticercosis: methotrexate as a corticosteroid-sparing agent.

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  • 1Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.


Treatment of neurocysticercosis with larvicidal agents is commonly complicated by seizures and transient neurologic deficits as a result of the host immune response to dying cysts. We report a case in which treatment with high-dose praziquantel resulted in prolonged perilesional edema requiring use of corticosteroids and corticosteroid-sparing agents for >1 year, suggesting a role for methotrexate in the management of this condition.

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