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Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6969-73. Epub 2003 May 13.

Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription.

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  • 1Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.


The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation.

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