Z Immunitatsforsch Exp Klin Immunol. 1975 May;148(5):425-30.

Adjuvancy of streptococcal nucleic acids.

Bültmann B, Finger H, Heymer B, Schachenmayr W, Hof H, Haferkamp O.

Abstract

A study was performed to find out whether or not RNA and DNA isolated from Group A streptococcal cytoplasm does possess adjuvant activity. The findings obtained indicate that the adjuvancy of streptococcal RNA is very similar to that of poly I:C. The adjuvant activity of poly I:C is characterized by its capacity to increase the number of pre-existing hemolysin-producing spleen cells and by its ability to increase the development of 19S and 7S producers early in the 12-day-period of primary immune response. The adjuvancy of streptococcal DNA was considerably less pronounced than that of RNA. Neither poly I:C nor streptococcal RNA and DNA were found to be capable of increasing the process of priming for the secondary immune response.

PMID:: 127450; [PubMed - indexed for MEDLINE]

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Time relationships between injection of antigen and adjuvant. 3. Adjuvancy of Bordetella pertussis given at various times after the primary antigenic stimulus. [Infect Immun. 1972]
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