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J Virol. 2003 Jun;77(11):6580-4.

The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P.

Author information

  • 1Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. RTripp@cdc.gov

Abstract

Respiratory syncytial virus (RSV) infection in the neonate can alter respiratory rates, i.e., lead to episodes of apnea. We show that RSV G glycoprotein reduces respiratory rates associated with the induction of substance P (SP) and G glycoprotein-CX3CR1 interaction, an effect that is inhibited by treatment with anti-G glycoprotein, anti-SP, or anti-CX3CR1 monoclonal antibodies. These data suggest new approaches for treating some aspects of RSV disease.

PMID:
12743318
[PubMed - indexed for MEDLINE]
PMCID:
PMC155004
Free PMC Article

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