EMBO J. 2003 May 15;22(10):2318-23.

Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression.

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Institute of Biochemistry and Genetics, Department of Clinical-Biological Sciences, University of Basel, Vesalgasse 1, Switzerland. gerhard.christofori@unibas.ch

Abstract

Changes in cell-cell and cell-matrix adhesion accompany the transition from benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination of tumour cells. This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy.

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Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression.

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