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Genome Res. 2003 Jun;13(6A):1029-41. Epub 2003 May 12.

Genome function and nuclear architecture: from gene expression to nanoscience.

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  • 1The Jackson Laboratory, Bar Harbor, Maine 04609, USA.


Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.

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